Postdoc Opportunity in Pediatric Leukemia Research: »Drug Discovery and Immunotherapy using pediatric AML patient derived xenografts (PDX)»
07.10.2024
Universitätsklinikum Frankfurt
Frankfurt am Main
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Postdoc Opportunity in Pediatric Leukemia Research: »Drug Discovery and Immunotherapy using pediatric AML patient derived xenografts (PDX)»
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Frankfurt am Main
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Postdoc Opportunity in Pediatric Leukemia Research: »Drug Discovery and Immunotherapy using pediatric AML patient derived xenografts (PDX)»
Frankfurt am Main
Aktualität: 07.10.2024
Anzeigeninhalt:
07.10.2024, Universitätsklinikum Frankfurt
Frankfurt am Main
Postdoc Opportunity in Pediatric Leukemia Research: »Drug Discovery and Immunotherapy using pediatric AML patient derived xenografts (PDX)»
Über uns:
"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital.
Aufgaben:
- Utilizing drug, shRNA, CRISPR-Cas9 and Cas13 libraries, and state-of-the-art cellular immunotherapeutics (NK, CAR-NK, CIK, CAR-CIK, CAR-T) the project aims to establish potent drug targets, drug combinations and cellular immunotherapy that efficiently target AML in vitro and in vivo using these PDX models.
- Furthermore, you will maintain and expand the PDX biobank, apply gene expression and single-nucleotide variants (SNV)-based characterization and perform in silico prediction of druggable targets based on these data sources, followed by high-throughput drug testing.
- You will also supervise and collaborate with a research technician to ensure smooth laboratory operations.
- Key techniques include the use of high-throughput platforms such as drug, shRNA, and CRISPR-Cas9/13 libraries, generation of cellular immunotherapeutics, as well as cellular assays with primary murine and human cells.
- Flow cytometry and gene expression analysis (RNA-Seq, Western blots) will be central to the project.
- Drugs and immunotherapeutics that successfully eliminate AML blasts while sparing normal CD34+-HSPCs will be further explored in PDX models, and promising candidates will undergo molecular and biochemical characterization to uncover their mechanisms of action.
- The outcomes from this research will contribute to finding novel treatment options for this life-threatening disease.
Qualifikationen:
- PhD and publication record in life sciences or related field
- Expertise in cell culture, flow cytometry, and molecular biology
- Experience with mouse handling and animal experiments (FELASA certification required)
- Ability to supervise and collaborate with a technician
- Proficiency in spoken and written English
- A collaborative team player with excellent communication skills
- Due to legal regulations, valid proof of measles immunity / measles vaccination is required.
Wir bieten:
- Collective agreement: In addition to an attractive salary based on a collective agreement with an annual special payment, you benefit from long-term security through company pension schemes
- Collaborative spirit : Excellent scientific environment & dedicated mentoring, training in novel cutting-edge techniques to study epigenetic mechanisms in leukemia cells, collaboration opportunities with national & international world-leading laboratories, participation in training and qualification programs of the MSNZ and the Goethe University
- Mobility: Free public transport in all Hessen (Free State Ticket Hessen)
- Campus: Our attractive university hospital campus offers a modern cafeteria, various cafes, and opportunities to rest in numerous green spaces. A walk on the riverside of the Main offers relaxation during breaks
- Work-Life-Balance: Part-time employment is possible, we offer childcare in our daycare center (if you have any questions, please contact UKF-Familienservice), child care during holidays
- Health Promotion: Benefit from our attractive health offers. We offer regular online and face-to-face courses on nutrition, relaxation, sports and exercise.
- Professional development: Internal and external training for your professional development
- Any questions? Many answers can be found in our FAQs for new employees. If you have any further questions, please do not hesitate to contact us.
Unser Kontakt:
Universitätsmedizin Frankfurt | Recruiting Team | Theodor-Stern-Kai 7 | 60590 Frankfurt am Main | Bitte reichen Sie Ihre Bewerbung ausschließlich über den Button »Online bewerben« ein. Rückfragen können Sie gerne an bewerbung@ukffm.de richten. Bitte beachten Sie, dass keine Unterlagen zurückgeschickt werden. | Folgen Sie uns auf Instagram ( @ukf_karriere ); XING , LinkedIn .
Weitere Informationen:
Women are underrepresented in these positions at the University Hospital Frankfurt. Applications from women are therefore particularly welcome. Disabled applicants are preferred if they have the same personal and professional qualifications.
Berufsfeld
Gesundheits-/Sozialwesen
Forschung & Entwicklung
Pharma, Chemie, Med., Biotechn.
Biologische, Klinische F&E
Labor
Bundesland
Standorte