"Knowledge becomes health" - we are filling this motto with life every day, developing new ideas and improv-ing old-established knowledge. The University Hospital Frankfurt has existed since 1914. Our around 8,500 employees contribute with their skills and knowledge to the 33 specialist clinics, theoretical clinical institutes, and administrative departments. The close connection of health care with research and teaching, as well as a climate of collegiality, internationality, and cross-professional cooperation characterize the university hospital. The Department of Psychiatry, Psychosomatic Medicine and Psychotherapy in Frankfurt investigates mental disorders along the life span with a focus on mood disorders (Treatment-resistant depression, bipolar disorder, suicidality), attention deficit hyperactivity disorder (ADHD) and schizophrenia. Our research teams converge highly interdisciplinary expertise in psychiatry, clinical and applied psychology, as well as neurobiology to elucidate the pathophysiological, genetic, and molecular mechanisms of these disorders as well as to identify novel tailored treatments in the sense of precision psychiatry. We make use of a diverse range of cutting-edge methods that follow the logic of translational/experimental medicine, with results from basic studies being rapidly translated to the bedside. Our methodological spectrum covers the fields of molecular biology and genetics, animal models, lifestyle modifications, neurophysiology, neuroimaging and clinical studies.